Evolving Thoughts On How CBD Works Because investigation continues into CBD's effectiveness, we're continually gaining knowledge. One significan
Evolving Thoughts On How CBD Works
Because investigation continues into CBD’s effectiveness, we’re continually gaining knowledge.
One significant change in opinion on CBD is whether it binds to cannabinoid receptors. While it used to be believed CBD binds to CB2 receptors, today things have changed. It appears CBD may heal in an entirely different manner.
The way CBD actually works is even more fascinating and subtle. By exerting influence on the ECS in secondary ways, CBD facilitates wellness.
How Does CBD Work: Reviewing Receptors and The ECS
The Endocannabinoid System is a term describing a system in the body that influences many functions happening behind the scenes. You don’t realize what your body is going through to keep the lights on but the ECS plays a huge role.
The’ system’ itself involves natural compounds your body makes named endocannabinoids. Furthermore, it involves a number of receptors on cells that bind with (connect to) those endocannabinoids. Lastly, there are fatty acids and enzymes that communicate with endocannabinoids. They get included in the umbrella of the ECS as well.
Some cannabinoids have very similar structures to endocannabinoids. Others, however, aren’t close enough to actually attach to receptors made to bind to endocannabinoids.
THC is a cannabinoid that is so similar to the endocannabinoid Anandamide that they share receptors. CBD, on the other hand, is close to some endocannabinoids that favor CB2 receptors, but not enough to form strong attachments.
Because of this, science now understands that CBD influences the actions of the fats and enzymes in the ECS. In turn, the endocannabinoid climate inside the body changes and produces several benefits.
How Does CBD Work: CBD And Anandamide
If you’re confused by the title of this section it’s because you’re paying attention. We just stated that THC and anandamide share a receptor and now we’re talking about CBD and anandamide. There’s a reason for that and you’ll see it in a moment.
Anandamide is a neurotransmitter described as the bliss molecule since it encourages happiness and a sensation of intoxication. Anandamide binds with your CB1 receptors and is linked to memory, hormones, depression, anxiety, appetite, pain, coordination, cognitive processes, motivation, as well as cancer cell development.
CBD shares a secondary anandamide connection because of the way CBD affects FAAH. Let’s take a closer look at how CBD can actually boost anandamide levels in the body.
How Does CBD Work: Hemp CBD And FAAH
CBD is special, it doesn’t actually bind very well with any endocannabinoid receptors. Researchers in the past believed CBD did bind to CB2, although the existing way of thinking rejects this theory. Instead, CBD alters how fast Anandamide breaks down. CBD actually slows FAAH, a fatty acid which breaks down Anandamide. Obviously, when it slows down the substance that breaks anandamide down, it leaves more anandamide available. In turn, that anandamide can couple with CB1 receptors and produce pain relief, bliss and increase appetite.
Furthermore, CBD affects many noncannabinoid receptors and ion channels also. For instance, CBD binds to TRPV1 receptors which mediate pain perception, inflammation and body temperature regulation.
CBD also stalls the “reuptake” of endogenous neurotransmitters and changes the binding activity of some G protein-coupled receptors.
Yet another CBD effect is triggering the five HT1A (hydroxytryptamine) serotonin receptor. More serotonin enhances mood as well as reduces anxiety.
How Does CBD Work: Updating Our Readers
You may see some older articles on this website that talk about CBD binding to CB2 receptors. We’ve published this as our most updated explanation of the current scientific understanding about CBD. As research continues we will keep you updated with the freshest information we have access to.