The interactive synergy between cannabis compounds is called the Entourage Effect. Once we explain this effect, you’ll understand why CBD or THC exclusive treatments fall short for many health conditions. Furthermore, many animal studies with cannabidiol utilize synthetic, single molecule CBD in studies. In comparison, whole plant extractions typically include THC, CBD and 400 trace compounds.
For example, the cannabinoid CBD has a well documented synergy with THC. CBD reduces THC’s negative effects and amplifies its benefits. Other cannabinoids along with marijuana’s many terpenes also contribute to the entourage effect.
As an outcome of investigation on the entourage effect, most folks today think that “whole plant medicine” is better than cannabis extracts including one cannabinoid only. It’s also obvious that research should study the entourage effect when conducting medical marijuana trials.
The Entourage Effect: What Is Whole Plant Medicine”?
Whole plant medicine is a term describing medicines utilizing the full spectrum of therapeutic compounds cannabis has to offer. All these healing agents that are processed out of CBD-only and THC- medicines have benefits for patients with varied conditions and symptoms. Although most cannabis today is bred to contain a disproportionately huge amount of THC compared to various other compounds, the benefits of chemical diversity has been realized as new strains emerge. Hopefully, we’ll soon start to see strains that not only narrow the gap between THC and CBD profiles, but emphasize other important cannabinoids and terpenes as well.
The Entourage Effect: Cannabinoids and Terpenes Interact
The way cannabinoids interact is interesting enough, but research looking into just how cannabinoids and terpenoids work together adds another level of intrigue.
An important voice in this discussion is Ethan Russo, M.D., a neurologist focused on cannabis compounds and how they affect the body. In his study “Taming THC: potential cannabis synergy and phytocannabinoid terpenoid entourage effects,” he details how cannabis compounds influence each other. Even small amounts of terpenes (fragrant oils ) really make a difference.
The terpene myrcene, for instance, can lower resistance in the blood brain barrier, enabling easier passage of some other beneficial chemicals.
On the other hand, Pinene helps counteract THC induced compromised cognition. A combination of terpenes pinene, myrcene, and caryophyllene all help unravel anxiety.
Furthermore, mixing limonene and linalool with the cannabinoid CBG shows promise in the treatment of MRSA, while THC plus CBN yields enhanced sedating effects. A combination of Linalool, limonene and CBD is even an emerging acne treatment.
The Entourage Effect: Nature Knows
These examples only scratch the surface of all the possible synergies made available to us by in whole plant therapies. As science unlocks the potential of these compound combinations, doctors can help more patients. It seems like nature knows more than she often gets credit for. Cannabis isn’t the only plant containing multifaceted benefits, after all.
It’s exciting to look ahead toward future research which continues to unlock the fascinating secrets of marijuana. We’ll continue to bring you the canna-info you need!